| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Interleukin-4 receptor subunit alpha (463-512 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL4R |
| Gene ID: | 3566 |
| Uniprot ID: | IL4RA_HUMAN |
| Immunogen Region: | 463-512 aa |
| Specificity: | IL-4R Alpha Polyclonal Antibody detects endogenous levels of IL-4R Alpha protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human IL-4R/CD124 at the amino acid range 463-512 |
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Protein Name | Interleukin-4 Receptor Subunit Alpha Il-4 Receptor Subunit Alpha Il-4r Subunit Alpha Il-4r-Alpha Il-4ra Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha Soluble Il-4 Receptor Subunit Alpha Soluble Il-4r-Alpha Sil4ralpha/Prot Il-4-Binding Protein Il4-Bp |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-4 Receptor Subunit Alpha antibody Anti-Il-4 Receptor Subunit Alpha antibody Anti-Il-4r Subunit Alpha antibody Anti-Il-4r-Alpha antibody Anti-Il-4ra antibody Anti-Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha antibody Anti-Soluble Il-4 Receptor Subunit Alpha antibody Anti-Soluble Il-4r-Alpha antibody Anti-Sil4ralpha/Prot antibody Anti-Il-4-Binding Protein antibody Anti-Il4-Bp antibody Anti-IL4R antibody Anti-IL4RA antibody Anti-582J2.1 antibody |
Information sourced from Uniprot.org