Anti-IL36RN/IL-1F5 antibody [SAA0398] {FITC} (STJA0028739)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Interleukin-36 Receptor Antagonist Protein antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0398 |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | IL36RN |
| Gene ID | 26525 |
| Uniprot ID | I36RA_HUMAN |
Additional Info
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-36 Receptor Antagonist Protein antibodyAnti-Il-36ra antibodyAnti-Fil1 Delta antibodyAnti-Il-1-Related Protein 3 antibodyAnti-Il-1rp3 antibodyAnti-Interleukin-1 Hy1 antibodyAnti-Il-1hy1 antibodyAnti-Interleukin-1 Delta antibodyAnti-Il-1 Delta antibodyAnti-Interleukin-1 Family Member 5 antibodyAnti-Il-1f5 antibodyAnti-Interleukin-1 Receptor Antagonist Homolog 1 antibodyAnti-Il-1ra Homolog 1 antibodyAnti-Interleukin-1-Like Protein 1 antibodyAnti-Il-1l1 antibodyAnti-IL36RN antibodyAnti-FIL1D antibodyAnti-IL1F5 antibodyAnti-IL1HY1 antibodyAnti-IL1L1 antibodyAnti-IL1RP3 antibodyAnti-UNQ1896 antibodyAnti-PRO4342 antibody |
Information sourced from Uniprot.org