Anti-IL36RN antibody (1-50 aa) (STJ97673)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Interleukin-36 receptor antagonist protein (1-50 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL36RN |
| Gene ID | 26525 |
| Uniprot ID | I36RA_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | IL-1F5 Polyclonal Antibody detects endogenous levels of IL-1F5 protein. |
Additional Info
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-36 Receptor Antagonist Protein antibodyAnti-Il-36ra antibodyAnti-Fil1 Delta antibodyAnti-Il-1-Related Protein 3 antibodyAnti-Il-1rp3 antibodyAnti-Interleukin-1 Hy1 antibodyAnti-Il-1hy1 antibodyAnti-Interleukin-1 Delta antibodyAnti-Il-1 Delta antibodyAnti-Interleukin-1 Family Member 5 antibodyAnti-Il-1f5 antibodyAnti-Interleukin-1 Receptor Antagonist Homolog 1 antibodyAnti-Il-1ra Homolog 1 antibodyAnti-Interleukin-1-Like Protein 1 antibodyAnti-Il-1l1 antibodyAnti-IL36RN antibodyAnti-FIL1D antibodyAnti-IL1F5 antibodyAnti-IL1HY1 antibodyAnti-IL1L1 antibodyAnti-IL1RP3 antibodyAnti-UNQ1896 antibodyAnti-PRO4342 antibody |
Information sourced from Uniprot.org