| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Interleukin-36 receptor antagonist protein (1-50 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL36RN |
| Gene ID: |
26525 |
| Uniprot ID: |
I36RA_HUMAN |
| Immunogen Region: |
1-50 aa |
| Specificity: |
IL-1F5 Polyclonal Antibody detects endogenous levels of IL-1F5 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN at the amino acid range 1-50 |
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-36 Receptor Antagonist Protein antibodyAnti-Il-36ra antibodyAnti-Fil1 Delta antibodyAnti-Il-1-Related Protein 3 antibodyAnti-Il-1rp3 antibodyAnti-Interleukin-1 Hy1 antibodyAnti-Il-1hy1 antibodyAnti-Interleukin-1 Delta antibodyAnti-Il-1 Delta antibodyAnti-Interleukin-1 Family Member 5 antibodyAnti-Il-1f5 antibodyAnti-Interleukin-1 Receptor Antagonist Homolog 1 antibodyAnti-Il-1ra Homolog 1 antibodyAnti-Interleukin-1-Like Protein 1 antibodyAnti-Il-1l1 antibodyAnti-IL36RN antibodyAnti-FIL1D antibodyAnti-IL1F5 antibodyAnti-IL1HY1 antibodyAnti-IL1L1 antibodyAnti-IL1RP3 antibodyAnti-UNQ1896 antibodyAnti-PRO4342 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
