Anti-IL31 antibody (24-164) (STJ117181)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL31 (24-164) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL31 |
| Gene ID | 386653 |
| Uniprot ID | IL31_HUMAN |
| Immunogen Region | 24-164 |
| Immunogen Sequence | SHTLPVRLLRPSDDVQKIVE ELQSLSKMLLKDVEEEKGVL VSQNYTLPCLSPDAQPPNNI HSPAIRAYLKTIRQLDNKSV IDEIIEHLDKLIFQDAPETN ISVPTDTHECKRFILTISQQ FSECMDLALKSLTSGAQQAT T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL31 (NP_001014358.1). |
Additional Info
| Tissue Specificity | Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. |
| Function | Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. |
| Protein Name | Interleukin-31Il-31 |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-31 antibodyAnti-Il-31 antibodyAnti-IL31 antibody |
Information sourced from Uniprot.org