| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL27RA (33-283) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL27RA |
| Gene ID: |
9466 |
| Uniprot ID: |
I27RA_HUMAN |
| Immunogen Region: |
33-283 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 33-283 of human IL27RA (NP_004834.1). |
| Immunogen Sequence: |
QGSAGPLQCYGVGPLGDLNC SWEPLGDLGAPSELHLQSQK YRSNKTQTVAVAAGRSWVAI PREQLTMSDKLLVWGTKAGQ PLWPPVFVNLETQMKPNAPR LGPDVDFSEDDPLEATVHWA PPTWPSHKVLICQFHYRRCQ EAAWTLLEPELKTIPLTPVE IQDLELATGYKVYGRCRMEK EEDLWGEWSPILSFQTPPSA PKDVWVSGNLCGTPGGEEPL LLWKAPGPCVQVSYKVWFW |
| Tissue Specificity | Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. |
| Function | Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. |
| Protein Name | Interleukin-27 Receptor Subunit AlphaIl-27 Receptor Subunit AlphaIl-27r Subunit AlphaIl-27r-AlphaIl-27raCytokine Receptor Wsx-1Cytokine Receptor-Like 1Type I T-Cell Cytokine ReceptorTccrZcytor1 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-27 Receptor Subunit Alpha antibodyAnti-Il-27 Receptor Subunit Alpha antibodyAnti-Il-27r Subunit Alpha antibodyAnti-Il-27r-Alpha antibodyAnti-Il-27ra antibodyAnti-Cytokine Receptor Wsx-1 antibodyAnti-Cytokine Receptor-Like 1 antibodyAnti-Type I T-Cell Cytokine Receptor antibodyAnti-Tccr antibodyAnti-Zcytor1 antibodyAnti-IL27RA antibodyAnti-CRL1 antibodyAnti-TCCR antibodyAnti-WSX1 antibodyAnti-UNQ296 antibodyAnti-PRO336 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
