Anti-IL26 antibody (50-154) [S5162RM] (STJ11105162)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Interleukin-26 (50-154) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5162RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL26 |
| Gene ID | 55801 |
| Uniprot ID | IL26_HUMAN |
| Immunogen Region | 50-154 |
| Immunogen Sequence | AWLKATIPEDRIKNIRLLKK KTKKQFMKNCQFQEQLLSFF MEDVFGQLQLQGCKKIRFVE DFHSLRQKLSHCISCASSAR EMKSITRMKRIFYRIGNKGI YKAIS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-154 of human IL26 (NP_060872.1). |
Additional Info
| Tissue Specificity | Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells.the expression is significantly increased in serum of patients with Crohn's disease (at protein level). |
| Function | May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. |
| Protein Name | Interleukin-26Il-26Protein Ak155 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-26 antibodyAnti-Il-26 antibodyAnti-Protein Ak155 antibodyAnti-IL26 antibodyAnti-AK155 antibody |
Information sourced from Uniprot.org