Anti-IL23A antibody (STJA0010179)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human IL23A
General Information
| Short Description | Rabbit polyclonal anti-Interleukin-23 subunit alpha for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL23A |
| Gene ID | 51561 |
| Uniprot ID | IL23A_HUMAN |
| Immunogen | Synthesized peptide derived from human IL23A |
| Specificity | This antibody detects endogenous levels of Human IL23A |
Additional Info
| Function | Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells. |
| Protein Name | Interleukin-23 Subunit AlphaIl-23 Subunit AlphaIl-23-AInterleukin-23 Subunit P19Il-23p19 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9020933 |
| Cellular Localisation | SecretedSecreted Upon Association With Il12b |
| Alternative Antibody Names | Anti-Interleukin-23 Subunit Alpha antibodyAnti-Il-23 Subunit Alpha antibodyAnti-Il-23-A antibodyAnti-Interleukin-23 Subunit P19 antibodyAnti-Il-23p19 antibodyAnti-IL23A antibodyAnti-SGRF antibodyAnti-UNQ2498 antibodyAnti-PRO5798 antibody |
Information sourced from Uniprot.org