Anti-IL20 antibody [SAA0389] {PE} (STJA0031630)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Interleukin-20 antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0389 |
| Isotype | IgG1k |
| Conjugation | PE |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | IL20 |
| Gene ID | 50604 |
| Uniprot ID | IL20_HUMAN |
Additional Info
| Function | Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB. Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2. Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes. |
| Protein Name | Interleukin-20Il-20Cytokine Zcyto10 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-20 antibodyAnti-Il-20 antibodyAnti-Cytokine Zcyto10 antibodyAnti-IL20 antibodyAnti-ZCYTO10 antibodyAnti-UNQ852 antibodyAnti-PRO1801 antibody |
Information sourced from Uniprot.org