• Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200

Anti-IL20 antibody (81-130 aa) (STJ98782)

SKU:
STJ98782

Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Interleukin-20 (81-130 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
ELISA 1:10000-20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL20
Gene ID: 50604
Uniprot ID: IL20_HUMAN
Immunogen Region: 81-130 aa
Specificity: The antibody detects endogenous IL-20
Immunogen: Synthetic peptide from the human protein at the amino acid range 81-130
Function Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation. Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB. Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2. Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes.
Protein Name Interleukin-20
Il-20
Cytokine Zcyto10
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-20 antibody
Anti-Il-20 antibody
Anti-Cytokine Zcyto10 antibody
Anti-IL20 antibody
Anti-ZCYTO10 antibody
Anti-UNQ852 antibody
Anti-PRO1801 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance