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![Anti-IL2 antibody [MQ1-17H12] {APC} (STJA0002141)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147925/292893/STJA0002141_1__45930.1631206914.jpg?c=1 "Anti-IL2 antibody [MQ1-17H12] {APC} (STJA0002141)")
Anti-IL2 antibody [MQ1-17H12] {APC} (STJA0002141)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationAPC
IsotypeIgG2ak
General Information
| Short Description | Rat monoclonal anti-Interleukin-2 for use in ICFC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICFC |
| Host | Rat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MQ1-17H12 |
| Isotype | IgG2ak |
| Conjugation | APC |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | IL2 |
| Gene ID | 3558 |
| Uniprot ID | IL2_HUMAN |
Additional Info
| Function | Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. |
| Protein Name | Interleukin-2Il-2T-Cell Growth FactorTcgfAldesleukin |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8877330Reactome: R-HSA-9020558Reactome: R-HSA-912526 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-2 antibodyAnti-Il-2 antibodyAnti-T-Cell Growth Factor antibodyAnti-Tcgf antibodyAnti-Aldesleukin antibodyAnti-IL2 antibody |
Information sourced from Uniprot.org