| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Il1rn |
| Gene ID: | 16181 |
| Uniprot ID: | IL1RA_MOUSE |
| Immunogen Region: | 27-178 |
| Immunogen Sequence: | RPSGKRPCKMQAFRIWDTNQ KTFYLRNNQLIAGYLQGPNI KLEEKIDMVPIDLHSVFLGI HGGKLCLSCAKSGDDIKLQL EEVNITDLSKNKEEDKRFTF IRSEKGPTTSFESAACPGWF LCTTLEADRPVSLTNTPEEP LIVTKFYFQEDQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-178 of mouse IL1RN (NP_001034790.1). |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Protein Name | Interleukin-1 Receptor Antagonist ProteinIl-1rnIl-1raIrapIl1 Inhibitor |
| Database Links | Reactome: R-MMU-9020702 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Antagonist Protein antibodyAnti-Il-1rn antibodyAnti-Il-1ra antibodyAnti-Irap antibodyAnti-Il1 Inhibitor antibodyAnti-Il1rn antibodyAnti-Il-1ra antibody |
Information sourced from Uniprot.org
