Anti-IL1RL1/ST2 (CNTO3914) antibody [CNTO3914] (STJA0032142)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal anti-IL1RL1/ST2 for use in ELISA and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Mouse |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | CNTO3914 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | Il1rl1 |
| Gene ID | 17082 |
| Uniprot ID | ILRL1_MOUSE |
Additional Info
| Post Translational Modifications | Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Interleukin-33 Receptor Alpha ChainLymphocyte Antigen 84Protein St2Protein T1 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-6811558Reactome: -MMU-9014843 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform B: Secreted |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Like 1 antibodyAnti-Interleukin-33 Receptor Alpha Chain antibodyAnti-Lymphocyte Antigen 84 antibodyAnti-Protein St2 antibodyAnti-Protein T1 antibodyAnti-Il1rl1 antibodyAnti-Ly84 antibodyAnti-St2 antibodyAnti-Ste2 antibody |
Information sourced from Uniprot.org