Anti-IL1RAP antibody (213-263 aa) (STJ193643)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human IL1AP at the amino acid range 213-263
General Information
| Short Description | Rabbit polyclonal anti-Interleukin-1 receptor accessory protein (213-263 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL1RAP |
| Gene ID | 3556 |
| Uniprot ID | IL1AP_HUMAN |
| Immunogen | Synthesized peptide derived from the human IL1AP at the amino acid range 213-263 |
| Immunogen Region | 213-263 aa |
| Specificity | This antibody detects endogenous levels of IL1AP at Human/Mouse/Rat |
Additional Info
| Function | Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone.binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Isoform 4: Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons. |
| Protein Name | Interleukin-1 Receptor Accessory ProteinIl-1 Receptor Accessory ProteinIl-1racpInterleukin-1 Receptor 3Il-1r-3Il-1r3 |
| Database Links | Reactome: R-HSA-1257604 Q9NPH3-1Reactome: R-HSA-388844 Q9NPH3-1Reactome: R-HSA-6811558 Q9NPH3-1Reactome: R-HSA-9014826 Q9NPH3-1Reactome: R-HSA-9014843 Q9NPH3-1Reactome: R-HSA-9020702 Q9NPH3-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Accessory Protein antibodyAnti-Il-1 Receptor Accessory Protein antibodyAnti-Il-1racp antibodyAnti-Interleukin-1 Receptor 3 antibodyAnti-Il-1r-3 antibodyAnti-Il-1r3 antibodyAnti-IL1RAP antibodyAnti-C3orf13 antibodyAnti-IL1R3 antibody |
Information sourced from Uniprot.org