Anti-IL1R2 antibody (Internal) (STJ72269)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-IL1R2 (Internal) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/IF/FC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 45kDa band observed in lysates of cell lines LNCaP and MOLT-4 (calculated MW o 45.4kDa according to NP_004624.1). Recommended concentration:0.3-1µg/ml. Primary incubation 1 hour |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | IL1R2 |
| Gene ID | 7850 |
| Uniprot ID | IL1R2_HUMAN |
| Accession Number | NP_004624.1; NP_001248348.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | QYNITRSIELRIKK |
| Specificity | This antibody is expected to cross-react with both reported isoforms (NP_004624.1; NP_001248348.1). Reported variants represent identical protein: NP_775465.1, NP_004624.1 |
Additional Info
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Type 2 antibodyAnti-Il-1r-2 antibodyAnti-Il-1rt-2 antibodyAnti-Il-1rt2 antibodyAnti-Cd121 Antigen-Like Family Member B antibodyAnti-Cdw121b antibodyAnti-Il-1 Type Ii Receptor antibodyAnti-Interleukin-1 Receptor Beta antibodyAnti-Il-1r-Beta antibodyAnti-Interleukin-1 Receptor Type Ii antibodyAnti-Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form antibodyAnti-Mil-1r2 antibodyAnti-Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form antibodyAnti-Sil-1r2 antibodyAnti-Sil-1rii antibodyAnti-IL1R2 antibodyAnti-IL1RB antibody |
Information sourced from Uniprot.org