| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL18RAP (500-550) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:10, 000IP: 1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
IL18RAP |
| Gene ID: |
8807 |
| Uniprot ID: |
I18RA_HUMAN |
| Immunogen Region: |
500-550 |
| Immunogen: |
Synthetic peptide taken within amino acid region 500-550 on human Interleukin-18 receptor accessory protein. |
| Tissue Specificity | Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus. Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon. Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). |
| Protein Name | Interleukin-18 Receptor Accessory ProteinIl-18 Receptor Accessory ProteinIl-18racpAccessory Protein-LikeAcplCd218 Antigen-Like Family Member BCdw218bIl-1r Accessory Protein-LikeIl-1racplInterleukin-1 Receptor 7Il-1r-7Il-1r7Interleukin-18 Receptor Accessory Protein-LikeInterleukin-18 Receptor BetaIl-18r-BetaIl-18rbetaCd Antigen Cd218b |
| Database Links | Reactome: R-HSA-9012546 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-18 Receptor Accessory Protein antibodyAnti-Il-18 Receptor Accessory Protein antibodyAnti-Il-18racp antibodyAnti-Accessory Protein-Like antibodyAnti-Acpl antibodyAnti-Cd218 Antigen-Like Family Member B antibodyAnti-Cdw218b antibodyAnti-Il-1r Accessory Protein-Like antibodyAnti-Il-1racpl antibodyAnti-Interleukin-1 Receptor 7 antibodyAnti-Il-1r-7 antibodyAnti-Il-1r7 antibodyAnti-Interleukin-18 Receptor Accessory Protein-Like antibodyAnti-Interleukin-18 Receptor Beta antibodyAnti-Il-18r-Beta antibodyAnti-Il-18rbeta antibodyAnti-Cd Antigen Cd218b antibodyAnti-IL18RAP antibodyAnti-IL1R7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using [KO Validated] NCOA2 Rabbit polyclonal antibody (STJ112318) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/92369/372743/STJ112318_1__72291.1713138814.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using [KO Validated] NCOA2 Rabbit polyclonal antibody (STJ112318) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
