Anti-IL17C antibody (19-197) (STJ112601)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL17C (19-197) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL17C |
| Gene ID | 27189 |
| Uniprot ID | IL17C_HUMAN |
| Immunogen Region | 19-197 |
| Immunogen Sequence | HHDPSLRGHPHSHGTPHCYS AEELPLGQAPPHLLARGAKW GQALPVALVSSLEAASHRGR HERPSATTQCPVLRPEEVLE ADTHQRSISPWRYRVDTDED RYPQKLAFAECLCRGCIDAR TGRETAALNSVRLLQSLLVL RRRPCSRDGSGLPTPGAFAF HTEFIHVPVGCTCVLPRSV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 19-197 of human IL17C (NP_037410.1). |
Additional Info
| Function | Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. |
| Protein Name | Interleukin-17cIl-17cCytokine Cx2 |
| Database Links | Reactome: R-HSA-448424 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-17c antibodyAnti-Il-17c antibodyAnti-Cytokine Cx2 antibodyAnti-IL17C antibodyAnti-UNQ561 antibodyAnti-PRO1122 antibody |
Information sourced from Uniprot.org