Anti-IL15 antibody (49-162) (STJ11105376)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Interleukin-15 (49-162) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL15 |
| Gene ID | 3600 |
| Uniprot ID | IL15_HUMAN |
| Immunogen Region | 49-162 |
| Immunogen Sequence | NWVNVISDLKKIEDLIQSMH IDATLYTESDVHPSCKVTAM KCFLLELQVISLESGDASIH DTVENLIILANNSLSSNGNV TESGCKECEELEEKNIKEFL QSFVHIVQMFINTS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 49-162 of human IL15 (NP_000576.1). |
Additional Info
| Tissue Specificity | Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus. |
| Function | Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4. |
| Protein Name | Interleukin-15Il-15 |
| Database Links | Reactome: R-HSA-8983432 |
| Cellular Localisation | Isoform Il15-S48aa: SecretedIsoform Il15-S21aa: CytoplasmNucleusIl15-S21aa Is Not SecretedBut Rather Is Stored IntracellularlyAppearing In The Nucleus And Cytoplasmic Components |
| Alternative Antibody Names | Anti-Interleukin-15 antibodyAnti-Il-15 antibodyAnti-IL15 antibody |
Information sourced from Uniprot.org