| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL12B (23-328) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL12B |
| Gene ID: |
3593 |
| Uniprot ID: |
IL12B_HUMAN |
| Immunogen Region: |
23-328 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-328 of human IL12B (NP_002178.2). |
| Immunogen Sequence: |
IWELKKDVYVVELDWYPDAP GEMVVLTCDTPEEDGITWTL DQSSEVLGSGKTLTIQVKEF GDAGQYTCHKGGEVLSHSLL LLHKKEDGIWSTDILKDQKE PKNKTFLRCEAKNYSGRFTC WWLTTISTDLTFSVKSSRGS SDPQGVTCGAATLSAERVRG DNKEYEYSVECQEDSACPAA EESLPIEVMVDAVHKLKYEN YTSSFFIRDIIKPDPPKNLQ LKPLKNSRQVEVSWEYPDT |
| Post Translational Modifications | Known to be C-mannosylated in the recombinant protein.it is not yet known for sure if the wild-type protein is also modified. |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40Nk Cell Stimulatory Factor Chain 2Nksf2 |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-12 Subunit Beta antibodyAnti-Il-12b antibodyAnti-Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibodyAnti-Clmf P40 antibodyAnti-Il-12 Subunit P40 antibodyAnti-Nk Cell Stimulatory Factor Chain 2 antibodyAnti-Nksf2 antibodyAnti-IL12B antibodyAnti-NKSF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
