| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Interleukin-11 receptor subunit alpha (300-380 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL11RA |
| Gene ID: |
3590 |
| Uniprot ID: |
I11RA_HUMAN |
| Immunogen Region: |
300-380 aa |
| Specificity: |
IL-11R Alpha Polyclonal Antibody detects endogenous levels of IL-11R Alpha protein. |
| Immunogen: |
Synthesized peptide derived from IL-11R Alpha at the amino acid range 300-380 |
| Post Translational Modifications | A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3. |
| Function | Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. Isoform HCR2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. |
| Protein Name | Interleukin-11 Receptor Subunit AlphaIl-11 Receptor Subunit AlphaIl-11r Subunit AlphaIl-11r-AlphaIl-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit AlphaSil-11rSil-11raSil11ra |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Interleukin-11 Receptor Subunit Alpha: MembraneSingle-Pass Type I Membrane ProteinSoluble Interleukin-11 Receptor Subunit Alpha: SecretedIsoform Hcr2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-11 Receptor Subunit Alpha antibodyAnti-Il-11 Receptor Subunit Alpha antibodyAnti-Il-11r Subunit Alpha antibodyAnti-Il-11r-Alpha antibodyAnti-Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha antibodyAnti-Sil-11r antibodyAnti-Sil-11ra antibodyAnti-Sil11ra antibodyAnti-IL11RA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
