Anti-IL10RB antibody (20-220) (STJ118126)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL10RB (20-220) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL10RB |
| Gene ID | 3588 |
| Uniprot ID | I10R2_HUMAN |
| Immunogen Region | 20-220 |
| Immunogen Sequence | MVPPPENVRMNSVNFKNILQ WESPAFAKGNLTFTAQYLSY RIFQDKCMNTTLTECDFSSL SKYGDHTLRVRAEFADEHSD WVNITFCPVDDTIIGPPGMQ VEVLADSLHMRFLAPKIENE YETWTMKNVYNSWTYNVQYW KNGTDEKFQITPQYDFEVLR NLEPWTTYCVQVRGFLPDRN KAGEWSEPVCEQTTHDETVP S |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human IL10RB (NP_000619.3). |
Additional Info
| Function | Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. |
| Protein Name | Interleukin-10 Receptor Subunit BetaIl-10 Receptor Subunit BetaIl-10r Subunit BetaIl-10rbCytokine Receptor Class-Ii Member 4Cytokine Receptor Family 2 Member 4Crf2-4Interleukin-10 Receptor Subunit 2Il-10r Subunit 2Il-10r2Cd Antigen Cdw210b |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8854691 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-10 Receptor Subunit Beta antibodyAnti-Il-10 Receptor Subunit Beta antibodyAnti-Il-10r Subunit Beta antibodyAnti-Il-10rb antibodyAnti-Cytokine Receptor Class-Ii Member 4 antibodyAnti-Cytokine Receptor Family 2 Member 4 antibodyAnti-Crf2-4 antibodyAnti-Interleukin-10 Receptor Subunit 2 antibodyAnti-Il-10r Subunit 2 antibodyAnti-Il-10r2 antibodyAnti-Cd Antigen Cdw210b antibodyAnti-IL10RB antibodyAnti-CRFB4 antibodyAnti-D21S58 antibodyAnti-D21S66 antibody |
Information sourced from Uniprot.org