Anti-IL-23R antibody (24-315 aa) [SRM5452] (STJ11107366)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal IL-23R (24-315 aa) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5452 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Il23r |
| Gene ID | 209590 |
| Uniprot ID | IL23R_MOUSE |
| Immunogen Region | 24-315 aa |
| Immunogen Sequence | GITSINCSGDMWVEPGEIFQ MGMNVSIYCQEALKHCRPRN LYFYKNGFKEEFDITRINRT TARIWYKGFSEPHAYMHCTA ECPGHFQETLICGKDISSGH PPDAPSNLTCVIYEYSGNMT CTWNTGKPTYIDTKYIVHVK SLETEEEQQYLASSYVKIST DSLQGSRKYLVWVQAVNSLG MENSQQLHVHLDDIVIPSAS IISRAETTNDTVPKTIVYWK SKTMIEKVFCEMRYKTTTN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-315 of mouse IL-23R (NP_653131.3). |
Additional Info
| Tissue Specificity | Expressed by Th1, Th2 and dendritic cells. |
| Post Translational Modifications | Phosphorylated in response to IL23. |
| Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
| Protein Name | Interleukin-23 ReceptorIl-23 ReceptorIl-23r |
| Database Links | Reactome: R-MMU-9020933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-23 Receptor antibodyAnti-Il-23 Receptor antibodyAnti-Il-23r antibodyAnti-Il23r antibody |
Information sourced from Uniprot.org