Anti-IKZF3 antibody (280-450) (STJ29426)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IKZF3 (280-450) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IKZF3 |
| Gene ID | 22806 |
| Uniprot ID | IKZF3_HUMAN |
| Immunogen Region | 280-450 |
| Immunogen Sequence | HCFDVNYNSSYMYEKESELI QTRMMDQAINNAISYLGAEA LRPLVQTPPAPTSEMVPVIS SMYPIALTRAEMSNGAPQEL EKKSIHLPEKSVPSERGLSP NNSGHDSTDTDSNHEERQNH IYQQNHMVLSRARNGMPLLK EVPRSYELLKPPPICPRDSV KVINKEGEVMD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2). |
Additional Info
| Tissue Specificity | Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. |
| Post Translational Modifications | Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells. |
| Function | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
| Protein Name | Zinc Finger Protein AiolosIkaros Family Zinc Finger Protein 3 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmIsoform 1: NucleusIsoform 3: NucleusIsoform 11: NucleusIsoform 14: NucleusIsoform 12: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Protein Aiolos antibodyAnti-Ikaros Family Zinc Finger Protein 3 antibodyAnti-IKZF3 antibodyAnti-ZNFN1A3 antibody |
Information sourced from Uniprot.org