| Short Description : | Rabbit monoclonal Zinc Finger Protein Aiolos antibody for use in WB, IF-P, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF-P/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM13231 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB, 1:500-1:1000IF-P, 1:50-1:200IHC-P, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IKZF3 |
| Gene ID: | 22806 |
| Uniprot ID: | IKZF3_HUMAN |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Immunogen Sequence: | Human |
| Post Translational Modifications | Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells. |
| Function | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
| Protein Name | Zinc Finger Protein AiolosIkaros Family Zinc Finger Protein 3 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmIsoform 1: NucleusIsoform 3: NucleusIsoform 11: NucleusIsoform 14: NucleusIsoform 12: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Protein Aiolos antibodyAnti-Ikaros Family Zinc Finger Protein 3 antibodyAnti-IKZF3 antibodyAnti-ZNFN1A3 antibody |
Information sourced from Uniprot.org
