Anti-IKBKAP antibody (1093-1332) (STJ112166)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IKBKAP (1093-1332) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ELP1 |
| Gene ID | 8518 |
| Uniprot ID | ELP1_HUMAN |
| Immunogen Region | 1093-1332 |
| Immunogen Sequence | LRLVYKYNRLDIIETNVKPS ILEAQKNYMAFLDSQTATFS RHKKRLLVVRELKEQAQQAG LDDEVPHGQESDLFSETSSV VSGSEMSGKYSHSNSRISAR SSKNRRKAERKKHSLKEGSP LEDLALLEALSEVVQNTENL KDEVYHILKVLFLFEFDEQG RELQKAFEDTLQLMERSLPE IWTLTYQQNSATPVLGPNST ANSIMASYQQQKTSVPVLDA ELFIPPKINRRTQWKLSLL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1093-1332 of human IKBKAP (NP_003631.2). |
Additional Info
| Function | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). |
| Protein Name | Elongator Complex Protein 1Elp1Ikappab Kinase Complex-Associated ProteinIkk Complex-Associated ProteinP150 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Elongator Complex Protein 1 antibodyAnti-Elp1 antibodyAnti-Ikappab Kinase Complex-Associated Protein antibodyAnti-Ikk Complex-Associated Protein antibodyAnti-P150 antibodyAnti-ELP1 antibodyAnti-IKAP antibodyAnti-IKBKAP antibody |
Information sourced from Uniprot.org