| Host: |
Mouse |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Insulin-like growth factor 2 mRNA-binding protein 3 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
8F11 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGF2BP3 |
| Gene ID: |
10643 |
| Uniprot ID: |
IF2B3_HUMAN |
| Specificity: |
IMP-3 Monoclonal Antibody detects endogenous levels of IMP-3 protein. |
| Immunogen: |
Purified recombinant fragment of human IMP-3 expressed in E. Coli. |
| Function | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. |
| Protein Name | Insulin-Like Growth Factor 2 Mrna-Binding Protein 3Igf2 Mrna-Binding Protein 3Imp-3Igf-Ii Mrna-Binding Protein 3Kh Domain-Containing Protein Overexpressed In CancerHkocVickz Family Member 3 |
| Database Links | Reactome: R-HSA-428359 |
| Cellular Localisation | NucleusCytoplasmP-BodyStress GranuleFound In Lamellipodia Of The Leading EdgeIn The Perinuclear RegionAnd Beneath The Plasma MembraneThe Subcytoplasmic Localization Is Cell Specific And Regulated By Cell Contact And GrowthLocalized At The Connecting Piece And The Tail Of The SpermatozoaColocalized With Cd44 Mrna In Rnp GranulesIn Response To Cellular StressSuch As Oxidative StressRecruited To Stress Granules |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor 2 Mrna-Binding Protein 3 antibodyAnti-Igf2 Mrna-Binding Protein 3 antibodyAnti-Imp-3 antibodyAnti-Igf-Ii Mrna-Binding Protein 3 antibodyAnti-Kh Domain-Containing Protein Overexpressed In Cancer antibodyAnti-Hkoc antibodyAnti-Vickz Family Member 3 antibodyAnti-IGF2BP3 antibodyAnti-IMP3 antibodyAnti-KOC1 antibodyAnti-VICKZ3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
