| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Insulin-like growth factor 2 mRNA-binding protein 2 (141-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGF2BP2 |
| Gene ID: |
10644 |
| Uniprot ID: |
IF2B2_HUMAN |
| Immunogen Region: |
141-190 aa |
| Specificity: |
IGF2-BP2 Polyclonal Antibody detects endogenous levels of IGF2-BP2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human IGF2BP2 at the amino acid range 141-190 |
| Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. |
| Protein Name | Insulin-Like Growth Factor 2 Mrna-Binding Protein 2Igf2 Mrna-Binding Protein 2Imp-2Hepatocellular Carcinoma Autoantigen P62Igf-Ii Mrna-Binding Protein 2Vickz Family Member 2 |
| Database Links | Reactome: R-HSA-428359 |
| Cellular Localisation | NucleusCytoplasmP-BodyStress GranuleLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasLocalizes At The Connecting Piece And The Tail Of The SpermatozoaIn Response To Cellular StressSuch As Oxidative StressRecruited To Stress Granules |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 antibodyAnti-Igf2 Mrna-Binding Protein 2 antibodyAnti-Imp-2 antibodyAnti-Hepatocellular Carcinoma Autoantigen P62 antibodyAnti-Igf-Ii Mrna-Binding Protein 2 antibodyAnti-Vickz Family Member 2 antibodyAnti-IGF2BP2 antibodyAnti-IMP2 antibodyAnti-VICKZ2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
