Anti-IFT57 antibody (170-429) (STJ29271)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IFT57 (170-429) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFT57 |
| Gene ID | 55081 |
| Uniprot ID | IFT57_HUMAN |
| Immunogen Region | 170-429 |
| Immunogen Sequence | VEELEEESVAEDDAELTLNK VDEEFVEEETDNEENFIDLN VLKAQTYHLDMNETAKQEDI LESTTDAAEWSLEVERVLPQ LKVTIRTDNKDWRIHVDQMH QHRSGIESALKETKGFLDKL HNEITRTLEKISSREKYINN QLENLVQEYRAAQAQLSEAK ERYQQGNGGVTERTRLLSEV MEELEKVKQEMEEKGSSMTD GAPLVKIKQSLTKLKQETVE MDIRIGIVEHTLLQSKLKE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1). |
Additional Info
| Tissue Specificity | Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level). |
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.however the relevance of such function remains unclear. |
| Protein Name | Intraflagellar Transport Protein 57 HomologDermal Papilla-Derived Protein 8Estrogen-Related Receptor Beta-Like Protein 1Hip1-Interacting ProteinMhs4r2 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyConcentrates Within The Inner Segment Of Cilia |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 57 Homolog antibodyAnti-Dermal Papilla-Derived Protein 8 antibodyAnti-Estrogen-Related Receptor Beta-Like Protein 1 antibodyAnti-Hip1-Interacting Protein antibodyAnti-Mhs4r2 antibodyAnti-IFT57 antibodyAnti-DERP8 antibodyAnti-ESRRBL1 antibodyAnti-HIPPI antibody |
Information sourced from Uniprot.org