Anti-IFT25 antibody (STJA0006848)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human IFT25
General Information
| Short Description | Rabbit polyclonal anti-Intraflagellar transport protein 25 homolog for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFT25 |
| Gene ID | 51668 |
| Uniprot ID | IFT25_HUMAN |
| Immunogen | Synthesized peptide derived from human IFT25 |
| Specificity | This antibody detects endogenous levels of IFT25 at Human, Mouse |
Additional Info
| Function | Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. |
| Protein Name | Intraflagellar Transport Protein 25 HomologHeat Shock Protein Beta-11Hspb11Heat Shock Protein Family B Member 11Placental Protein 25Pp25 |
| Database Links | Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCilium |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 25 Homolog antibodyAnti-Heat Shock Protein Beta-11 antibodyAnti-Hspb11 antibodyAnti-Heat Shock Protein Family B Member 11 antibodyAnti-Placental Protein 25 antibodyAnti-Pp25 antibodyAnti-IFT25 antibodyAnti-C1orf41 antibodyAnti-HSPB11 antibodyAnti-HSPC034 antibody |
Information sourced from Uniprot.org