| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Interferon lambda receptor 1 (Internal) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IFNLR1 |
| Gene ID: | 163702 |
| Uniprot ID: | INLR1_HUMAN |
| Immunogen Region: | Internal |
| Specificity: | IL-28R Alpha Polyclonal Antibody detects endogenous levels of IL-28R Alpha protein. |
| Immunogen: | Synthesized peptide derived from the Internal region of human IL-28R Alpha. |
| Post Translational Modifications | Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. |
| Function | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. |
| Protein Name | Interferon Lambda Receptor 1 Ifn-Lambda Receptor 1 Ifn-Lambda-R1 Cytokine Receptor Class-Ii Member 12 Cytokine Receptor Family 2 Member 12 Crf2-12 Interleukin-28 Receptor Subunit Alpha Il-28 Receptor Subunit Alpha Il-28r-Alpha Il-28ra Likely Interleukin Or Cytokine Receptor 2 Licr2 |
| Database Links | Reactome: R-HSA-449836 Reactome: R-HSA-8854691 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interferon Lambda Receptor 1 antibody Anti-Ifn-Lambda Receptor 1 antibody Anti-Ifn-Lambda-R1 antibody Anti-Cytokine Receptor Class-Ii Member 12 antibody Anti-Cytokine Receptor Family 2 Member 12 antibody Anti-Crf2-12 antibody Anti-Interleukin-28 Receptor Subunit Alpha antibody Anti-Il-28 Receptor Subunit Alpha antibody Anti-Il-28r-Alpha antibody Anti-Il-28ra antibody Anti-Likely Interleukin Or Cytokine Receptor 2 antibody Anti-Licr2 antibody Anti-IFNLR1 antibody Anti-IL28RA antibody Anti-LICR2 antibody |
Information sourced from Uniprot.org