| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IFNLR1 (21-228) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFNLR1 |
| Gene ID: |
163702 |
| Uniprot ID: |
INLR1_HUMAN |
| Immunogen Region: |
21-228 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 21-228 of human IFNLR1 (NP_734464.1). |
| Immunogen Sequence: |
RPRLAPPQNVTLLSQNFSVY LTWLPGLGNPQDVTYFVAYQ SSPTRRRWREVEECAGTKEL LCSMMCLKKQDLYNKFKGRV RTVSPSSKSPWVESEYLDYL FEVEPAPPVLVLTQTEEILS ANATYQLPPCMPPLDLKYEV AFWKEGAGNKTLFPVTPHGQ PVQITLQPAASEHHCLSART IYTFSVPKYSKFSKPTCFLL EVPEANWA |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. |
| Function | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. |
| Protein Name | Interferon Lambda Receptor 1Ifn-Lambda Receptor 1Ifn-Lambda-R1Cytokine Receptor Class-Ii Member 12Cytokine Receptor Family 2 Member 12Crf2-12Interleukin-28 Receptor Subunit AlphaIl-28 Receptor Subunit AlphaIl-28r-AlphaIl-28raLikely Interleukin Or Cytokine Receptor 2Licr2 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interferon Lambda Receptor 1 antibodyAnti-Ifn-Lambda Receptor 1 antibodyAnti-Ifn-Lambda-R1 antibodyAnti-Cytokine Receptor Class-Ii Member 12 antibodyAnti-Cytokine Receptor Family 2 Member 12 antibodyAnti-Crf2-12 antibodyAnti-Interleukin-28 Receptor Subunit Alpha antibodyAnti-Il-28 Receptor Subunit Alpha antibodyAnti-Il-28r-Alpha antibodyAnti-Il-28ra antibodyAnti-Likely Interleukin Or Cytokine Receptor 2 antibodyAnti-Licr2 antibodyAnti-IFNLR1 antibodyAnti-IL28RA antibodyAnti-LICR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
