Anti-IFNAR1 antibody [MAR1-5A3] {FITC} (STJA0028272)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Rat monoclonal Interferon Alpha/Beta Receptor 1 antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rat |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MAR1-5A3 |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 05 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months Protect from light Do not freeze |
Target Information
| Gene Symbol | Ifnar1 |
| Gene ID | 15975 |
| Uniprot ID | INAR1_MOUSE |
Additional Info
| Function | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. |
| Protein Name | Interferon Alpha/Beta Receptor 1Ifn-R-1Ifn-Alpha/Beta Receptor 1Type I Interferon Receptor 1 |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLate EndosomeLysosomeInterferon Binding Triggers Internalization Of The Receptor From The Cell Membrane Into Endosomes And Then Into Lysosomes |
| Alternative Antibody Names | Anti-Interferon Alpha/Beta Receptor 1 antibodyAnti-Ifn-R-1 antibodyAnti-Ifn-Alpha/Beta Receptor 1 antibodyAnti-Type I Interferon Receptor 1 antibodyAnti-Ifnar1 antibodyAnti-Ifar antibodyAnti-Ifnar antibody |
Information sourced from Uniprot.org