Anti-IFITM3 antibody (1-50) {Biotin} (STJ501405)

SKU:
STJ501405-100

£546.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IFITM3 (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IFITM3
Gene ID: 10410
Uniprot ID: IFM3_HUMAN
Immunogen Region: 1-50
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human Interferon-induced transmembrane protein 3.
Post Translational Modifications Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus and hepatitis C virus (HCV). Has no effect on anti-SARS-CoV-2 activity. Not glycosylated. Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site. Phosphorylation at Tyr-20 is required for endosomal and lysosomal location.
Function IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome. Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane.
Protein Name Interferon-Induced Transmembrane Protein 3
Dispanin Subfamily A Member 2b
Dspa2b
Interferon-Inducible Protein 1-8u
Database Links Reactome: R-HSA-909733
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Late Endosome Membrane
Early Endosome Membrane
Lysosome Membrane
Cytoplasm
Perinuclear Region
Co-Localizes With Bri3 Isoform 1 At The Perinuclear Region
Alternative Antibody Names Anti-Interferon-Induced Transmembrane Protein 3 antibody
Anti-Dispanin Subfamily A Member 2b antibody
Anti-Dspa2b antibody
Anti-Interferon-Inducible Protein 1-8u antibody
Anti-IFITM3 antibody

Information sourced from Uniprot.org

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