Anti-IFIT3 antibody (100-200) (STJ115939)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IFIT3 (100-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFIT3 |
| Gene ID | 3437 |
| Uniprot ID | IFIT3_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | YAWIYYHMGRLSEAQAYVDK VRQVCQKFANPYSMECPELE CEEGWTRLKCGRNERAKMCF EKALEEKPKDPECSSGMAIA MFRLEEKPEKQFSVDALKQA M |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse IFIT3 (NP_034631.1). |
Additional Info
| Tissue Specificity | Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. |
| Function | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 3Ifit-3Cig49Isg-60Interferon-Induced 60 Kda ProteinIfi-60kInterferon-Induced Protein With Tetratricopeptide Repeats 4Ifit-4Retinoic Acid-Induced Gene G ProteinP60Rig-G |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Interferon-Induced Protein With Tetratricopeptide Repeats 3 antibodyAnti-Ifit-3 antibodyAnti-Cig49 antibodyAnti-Isg-60 antibodyAnti-Interferon-Induced 60 Kda Protein antibodyAnti-Ifi-60k antibodyAnti-Interferon-Induced Protein With Tetratricopeptide Repeats 4 antibodyAnti-Ifit-4 antibodyAnti-Retinoic Acid-Induced Gene G Protein antibodyAnti-P60 antibodyAnti-Rig-G antibodyAnti-IFIT3 antibodyAnti-CIG-49 antibodyAnti-IFI60 antibodyAnti-IFIT4 antibodyAnti-ISG60 antibody |
Information sourced from Uniprot.org