Anti-IFIT2 antibody (273-472) (STJ115708)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IFIT2 (273-472) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFIT2 |
| Gene ID | 3433 |
| Uniprot ID | IFIT2_HUMAN |
| Immunogen Region | 273-472 |
| Immunogen Sequence | ALEYIPNNAYLHCQIGCCYR AKVFQVMNLRENGMYGKRKL LELIGHAVAHLKKADEANDN LFRVCSILASLHALADQYED AEYYFQKEFSKELTPVAKQL LHLRYGNFQLYQMKCEDKAI HHFIEGVKINQKSREKEKMK DKLQKIAKMRLSKNGADSEA LHVLAFLQELNEKMQQADED SERGLESGSLIPSASSWNGE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4). |
Additional Info
| Function | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 2Ifit-2Isg-54 KInterferon-Induced 54 Kda ProteinIfi-54kP54 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Interferon-Induced Protein With Tetratricopeptide Repeats 2 antibodyAnti-Ifit-2 antibodyAnti-Isg-54 K antibodyAnti-Interferon-Induced 54 Kda Protein antibodyAnti-Ifi-54k antibodyAnti-P54 antibodyAnti-IFIT2 antibodyAnti-CIG-42 antibodyAnti-G10P2 antibodyAnti-IFI54 antibodyAnti-ISG54 antibody |
Information sourced from Uniprot.org