Anti-IFIT1 antibody (41-90 aa) (STJ93640)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human IFIT1 at the amino acid range 41-90
General Information
| Short Description | Rabbit polyclonal anti-Interferon-induced protein with tetratricopeptide repeats 1 (41-90 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFIT1 |
| Gene ID | 3434 |
| Uniprot ID | IFIT1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human IFIT1 at the amino acid range 41-90 |
| Immunogen Region | 41-90 aa |
| Specificity | IFI-56K Polyclonal Antibody detects endogenous levels of IFI-56K protein. |
Additional Info
| Function | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families. |
| Protein Name | Antiviral Innate Immune Response Effector Ifit1Ifit-1Interferon-Induced 56 Kda ProteinIfi-56kP56Interferon-Induced Protein With Tetratricopeptide Repeats 1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Antiviral Innate Immune Response Effector Ifit1 antibodyAnti-Ifit-1 antibodyAnti-Interferon-Induced 56 Kda Protein antibodyAnti-Ifi-56k antibodyAnti-P56 antibodyAnti-Interferon-Induced Protein With Tetratricopeptide Repeats 1 antibodyAnti-IFIT1 antibodyAnti-G10P1 antibodyAnti-IFI56 antibodyAnti-IFNAI1 antibodyAnti-ISG56 antibody |
Information sourced from Uniprot.org