Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-IFI27 (1-100) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
IFI27 |
Gene ID: |
3429 |
Uniprot ID: |
IFI27_HUMAN |
Immunogen Region: |
1-100 |
Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFI27 (NP_005523.3). |
Immunogen Sequence: |
MEASALTSSAVTSVAKVVRV ASGSAVVLPLARIATVVIGG VVAVPMVLSAMGFTAAGIAS SSIAAKMMSAAAIANGGGVA SGSLVATLQSLGATGLSGLT |
Post Translational Modifications | Ubiquitinated by TRIM21 via 'Lys-6'-linked ubiquitin chains leading to IFI27 mitochondrial migration. |
Function | Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Also functions in TNFSF10-induced apoptosis. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. May thereby play a role in the vascular response to injury. In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV. May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A. Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21. |
Protein Name | Interferon Alpha-Inducible Protein 27 - MitochondrialP27Interferon Alpha-Induced 11.5 Kda ProteinInterferon-Stimulated Gene 12a ProteinIsg12(AIsg12a |
Database Links | Reactome: R-HSA-909733 |
Cellular Localisation | Mitochondrion MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEndoplasmic Reticulum MembraneExclusive Localizations In Either The Nucleus Or The Mitochondrion Have Been Reported |
Alternative Antibody Names | Anti-Interferon Alpha-Inducible Protein 27 - Mitochondrial antibodyAnti-P27 antibodyAnti-Interferon Alpha-Induced 11.5 Kda Protein antibodyAnti-Interferon-Stimulated Gene 12a Protein antibodyAnti-Isg12(A antibodyAnti-Isg12a antibodyAnti-IFI27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance