Anti-IDS antibody (Internal) (STJ71754)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-IDS (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx. 60kDa band observed in Human Liver lysates (calculated MW of 61.9kDa according to NP_000193.1). Recommended concentration: 0.1-0.3µg/ml.IHC: In paraffin embedded Human Pla |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | IDS |
| Gene ID | 3423 |
| Uniprot ID | IDS_HUMAN |
| Accession Number | NP_000193.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | KHFRFRDLEEDP |
| Specificity | This antibody is expected to recognize isoform a (NP_000193.1). |
Additional Info
| Post Translational Modifications | Synthesized as a 75-kDa precursor form in the endoplasmic reticulum (ER), and then processed by proteolytic cleavage through various intermediates to yield a 55-kDa mature form, with the release of an 18 kDa polypeptide. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. |
| Protein Name | Iduronate 2-SulfataseAlpha-L-Iduronate Sulfate SulfataseIdursulfase Cleaved Into - Iduronate 2-Sulfatase 42 Kda Chain - Iduronate 2-Sulfatase 14 Kda Chain |
| Database Links | Reactome: R-HSA-2024096Reactome: R-HSA-2024101Reactome: R-HSA-2206296 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Iduronate 2-Sulfatase antibodyAnti-Alpha-L-Iduronate Sulfate Sulfatase antibodyAnti-Idursulfase Cleaved Into - Iduronate 2-Sulfatase 42 Kda Chain - Iduronate 2-Sulfatase 14 Kda Chain antibodyAnti-IDS antibodyAnti-SIDS antibody |
Information sourced from Uniprot.org