Anti-IDS antibody (34-290) (STJ24123)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IDS (34-290) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IDS |
| Gene ID | 3423 |
| Uniprot ID | IDS_HUMAN |
| Immunogen Region | 34-290 |
| Immunogen Sequence | TDALNVLLIIVDDLRPSLGC YGDKLVRSPNIDQLASHSLL FQNAFAQQAVCAPSRVSFLT GRRPDTTRLYDFNSYWRVHA GNFSTIPQYFKENGYVTMSV GKVFHPGISSNHTDDSPYSW SFPPYHPSSEKYENTKTCRG PDGELHANLLCPVDVLDVPE GTLPDKQSTEQAIQLLEKMK TSASPFFLAVGYHKPHIPFR YPKEFQKLYPLENITLAPDP EVPDGLPPVAYNPWMDIRQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 34-290 of human IDS (NP_000193.1). |
Additional Info
| Tissue Specificity | Liver, kidney, lung, and placenta. |
| Post Translational Modifications | Synthesized as a 75-kDa precursor form in the endoplasmic reticulum (ER), and then processed by proteolytic cleavage through various intermediates to yield a 55-kDa mature form, with the release of an 18 kDa polypeptide. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. |
| Protein Name | Iduronate 2-SulfataseAlpha-L-Iduronate Sulfate SulfataseIdursulfase Cleaved Into - Iduronate 2-Sulfatase 42 Kda Chain - Iduronate 2-Sulfatase 14 Kda Chain |
| Database Links | Reactome: R-HSA-2024096Reactome: R-HSA-2024101Reactome: R-HSA-2206296 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Iduronate 2-Sulfatase antibodyAnti-Alpha-L-Iduronate Sulfate Sulfatase antibodyAnti-Idursulfase Cleaved Into - Iduronate 2-Sulfatase 42 Kda Chain - Iduronate 2-Sulfatase 14 Kda Chain antibodyAnti-IDS antibodyAnti-SIDS antibody |
Information sourced from Uniprot.org