Anti-IDH1 antibody [SRM14726] (STJ11109456)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal IDH1 antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14726 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:5000IF/ICC, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IDH1 |
| Gene ID | 3417 |
| Uniprot ID | IDHC_HUMAN |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
Additional Info
| Post Translational Modifications | Acetylation at Lys-374 dramatically reduces catalytic activity. |
| Function | Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. |
| Protein Name | Isocitrate Dehydrogenase Nadp CytoplasmicIdhIdh1Cytosolic Nadp-Isocitrate DehydrogenaseIdpcNadp(+-Specific IcdhOxalosuccinate Decarboxylase |
| Database Links | Reactome: R-HSA-2978092Reactome: R-HSA-389542Reactome: R-HSA-6798695Reactome: R-HSA-9033241Reactome: R-HSA-9818025 |
| Cellular Localisation | CytoplasmCytosolPeroxisome |
| Alternative Antibody Names | Anti-Isocitrate Dehydrogenase Nadp Cytoplasmic antibodyAnti-Idh antibodyAnti-Idh1 antibodyAnti-Cytosolic Nadp-Isocitrate Dehydrogenase antibodyAnti-Idpc antibodyAnti-Nadp(+-Specific Icdh antibodyAnti-Oxalosuccinate Decarboxylase antibodyAnti-IDH1 antibodyAnti-PICD antibody |
Information sourced from Uniprot.org