| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-IDH1 (153-164) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000. WB: Approx 48kDa band observed in lysates of cell line HepG2 and of Mouse Liver (calculated MW of 46.7kDa according to NP_005887.2). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | IDH1 |
| Gene ID: | 3417 |
| Uniprot ID: | IDHC_HUMAN |
| Immunogen Region: | 153-164 |
| Accession Number: | NP_005887.2 |
| Immunogen Sequence: | EITYTPSDGTQK |
| Function | Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. |
| Protein Name | Isocitrate Dehydrogenase Nadp Cytoplasmic Idh Idh1 Cytosolic Nadp-Isocitrate Dehydrogenase Idpc Nadp(+-Specific Icdh Oxalosuccinate Decarboxylase |
| Database Links | Reactome: R-HSA-2978092 Reactome: R-HSA-389542 Reactome: R-HSA-6798695 Reactome: R-HSA-9033241 Reactome: R-HSA-9818025 |
| Cellular Localisation | Cytoplasm Cytosol Peroxisome |
| Alternative Antibody Names | Anti-Isocitrate Dehydrogenase Nadp Cytoplasmic antibody Anti-Idh antibody Anti-Idh1 antibody Anti-Cytosolic Nadp-Isocitrate Dehydrogenase antibody Anti-Idpc antibody Anti-Nadp(+-Specific Icdh antibody Anti-Oxalosuccinate Decarboxylase antibody Anti-IDH1 antibody Anti-PICD antibody |
Information sourced from Uniprot.org