Anti-ID3 antibody (1-119) (STJ27328)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ID3 (1-119) antibody for use in IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ID3 |
| Gene ID | 3399 |
| Uniprot ID | ID3_HUMAN |
| Immunogen Region | 1-119 |
| Immunogen Sequence | MKALSPVRGCYEAVCCLSER SLAIARGRGKGPAAEEPLSL LDDMNHCYSRLRELVPGVPR GTQLSQVEILQRVIDYILDL QVVLAEPAPGPPDGPHLPIQ TAELTPELVISNDKRSFCH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human ID3 (NP_002158.3). |
Additional Info
| Tissue Specificity | Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain. |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. |
| Protein Name | Dna-Binding Protein Inhibitor Id-3Class B Basic Helix-Loop-Helix Protein 25Bhlhb25Helix-Loop-Helix Protein Heir-1Id-Like Protein Inhibitor Hlh 1r21Inhibitor Of Dna Binding 3Inhibitor Of Differentiation 3 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Binding Protein Inhibitor Id-3 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 25 antibodyAnti-Bhlhb25 antibodyAnti-Helix-Loop-Helix Protein Heir-1 antibodyAnti-Id-Like Protein Inhibitor Hlh 1r21 antibodyAnti-Inhibitor Of Dna Binding 3 antibodyAnti-Inhibitor Of Differentiation 3 antibodyAnti-ID3 antibodyAnti-1R21 antibodyAnti-BHLHB25 antibodyAnti-HEIR1 antibody |
Information sourced from Uniprot.org