| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ICT1 (30-206) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MRPL58 |
| Gene ID: |
3396 |
| Uniprot ID: |
ICT1_HUMAN |
| Immunogen Region: |
30-206 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-206 of human ICT1 (NP_001536.1). |
| Immunogen Sequence: |
LHKQKDGTEFKSIYSLDKLY PESQGSDTAWRVPNGAKQAD SDIPLDRLTISYCRSSGPGG QNVNKVNSKAEVRFHLATAE WIAEPVRQKIAITHKNKINR LGELILTSESSRYQFRNLAD CLQKIRDMITEASQTPKEPT KEDVKLHRIRIENMNRERLR QKRIHSAVKTSRRVDMD |
| Tissue Specificity | Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells. |
| Post Translational Modifications | Methylation of glutamine in the GGQ triplet by HEMK1. |
| Function | Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. |
| Protein Name | Large Ribosomal Subunit Protein Ml6239s Ribosomal Protein L58 - MitochondrialMrp-L58Digestion Substraction 1Ds-1Immature Colon Carcinoma Transcript 1 ProteinPeptidyl-Trna Hydrolase Ict1 - Mitochondrial |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ml62 antibodyAnti-39s Ribosomal Protein L58 - Mitochondrial antibodyAnti-Mrp-L58 antibodyAnti-Digestion Substraction 1 antibodyAnti-Ds-1 antibodyAnti-Immature Colon Carcinoma Transcript 1 Protein antibodyAnti-Peptidyl-Trna Hydrolase Ict1 - Mitochondrial antibodyAnti-MRPL58 antibodyAnti-DS1 antibodyAnti-ICT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
