Anti-ICOS ligand/B7-H2 antibody (Internal) (STJ73466)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ICOS ligand/B7-H2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 33kDa band observed in Human Lymph Node lysates (calculated MW of 33.3kDa according to NP_056074.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ICOSLG |
| Gene ID | 23308 |
| Uniprot ID | ICOSL_HUMAN |
| Accession Number | NP_056074.1; NP_001269979.1; NP_001269980.1; NP_001269981.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | SQTGNDIGERDKIT |
| Specificity | This antibody is expected to recognize all reported isoforms (NP_056074.1; NP_001269979.1; NP_001269980.1; NP_001269981.1). |
Additional Info
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1Cd Antigen Cd275 |
| Database Links | Reactome: R-HSA-388841 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Icos Ligand antibodyAnti-B7 Homolog 2 antibodyAnti-B7-H2 antibodyAnti-B7-Like Protein Gl50 antibodyAnti-B7-Related Protein 1 antibodyAnti-B7rp-1 antibodyAnti-Cd Antigen Cd275 antibodyAnti-ICOSLG antibodyAnti-B7H2 antibodyAnti-B7RP1 antibodyAnti-ICOSL antibodyAnti-KIAA0653 antibody |
Information sourced from Uniprot.org