| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ICK (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CILK1 |
| Gene ID: |
22858 |
| Uniprot ID: |
CILK1_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ICK (NP_057597.2). |
| Immunogen Sequence: |
MNRYTTIRQLGDGTYGSVLL GRSIESGELIAIKKMKRKFY SWEECMNLREVKSLKKLNHA NVVKLKEVIRENDHLYFIFE YMKENLYQLIKERNKLFPES AIRNIMYQILQGLAFIHKHG FFHRDLKPENLLCMGPELVK IADFGLAREIRSKPPYTDYV STRWYRAPEVLLRSTNYSSP IDVWAVGCIMAEVYTLRPLF PGASEIDTIFKICQVLGTPK KTDWPEGYQLSSAMNFRWP |
| Tissue Specificity | Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. |
| Post Translational Modifications | Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 increases kinase activity. |
| Function | Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity. |
| Protein Name | Serine/Threonine-Protein Kinase IckCiliogenesis Associated Kinase 1Intestinal Cell KinaseHickLaryngeal Cancer Kinase 2Lck2Mak-Related KinaseMrk |
| Cellular Localisation | NucleusCytoplasmCytosolCell ProjectionCiliumCytoskeletonCilium Basal BodyAlso Found At The Ciliary TipNuclear Localization Has Been Observed With A Gfp-Tagged Construct In Transfected Hela CellsIsoform 2: CytoplasmPredominant Cytoplasmic Localization Has Been Observed With A N-Terminally Gfp-Tagged Construct |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Ick antibodyAnti-Ciliogenesis Associated Kinase 1 antibodyAnti-Intestinal Cell Kinase antibodyAnti-Hick antibodyAnti-Laryngeal Cancer Kinase 2 antibodyAnti-Lck2 antibodyAnti-Mak-Related Kinase antibodyAnti-Mrk antibodyAnti-CILK1 antibodyAnti-ICK antibodyAnti-KIAA0936 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
