Anti-ICAM1 antibody (28-480) (STJ27566)

Name: Anti-ICAM1 antibody (28-480) (STJ27566)
SKU: STJ27566
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ27566

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Short Description	Rabbit polyclonal ICAM1 (28-480) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:5000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ICAM1
Gene ID	3383
Uniprot ID	ICAM1_HUMAN
Immunogen Region	28-480
Immunogen Sequence	QTSVSPSKVILPRGGSVLVT CSTSCDQPKLLGIETPLPKK ELLLPGNNRKVYELSNVQED SQPMCYSNCPDGQSTAKTFL TVYWTPERVELAPLPSWQPV GKNLTLRCQVEGGAPRANLT VVLLRGEKELKREPAVGEPA EVTTTVLVRRDHHGANFSCR TELDLRPQGLELFENTSAPY QLQTFVLPATPPQLVSPRVL EVDTQGTVVCSLDGLFPVSE AQVHLALGDQRLNPTVTYG
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 28-480 of human ICAM-1/CD54 (NP_000192.2).

Post Translational Modifications	Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Protein Name	Intercellular Adhesion Molecule 1 Icam-1 Major Group Rhinovirus Receptor Cd Antigen Cd54
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-216083 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-877300
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Intercellular Adhesion Molecule 1 antibody Anti-Icam-1 antibody Anti-Major Group Rhinovirus Receptor antibody Anti-Cd Antigen Cd54 antibody Anti-ICAM1 antibody

Information sourced from Uniprot.org