Anti-IBTK antibody (410-490 aa) (STJ190257)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 410-490
General Information
| Short Description | Rabbit polyclonal anti-Inhibitor of Bruton tyrosine kinase (410-490 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IBTK |
| Gene ID | 25998 |
| Uniprot ID | IBTK_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 410-490 |
| Immunogen Region | 410-490 aa |
| Specificity | IBTK Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. |
| Protein Name | Inhibitor Of Bruton Tyrosine KinaseIbtk |
| Database Links | |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinTranslocates To The Plasma Membrane Upon Igm StimulationIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Inhibitor Of Bruton Tyrosine Kinase antibodyAnti-Ibtk antibodyAnti-IBTK antibodyAnti-BTKI antibodyAnti-KIAA1417 antibody |
Information sourced from Uniprot.org