Anti-IAPP antibody (1-50 aa) (STJ91590)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Amylin at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Islet amyloid polypeptide (1-50 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IAPP |
| Gene ID | 3375 |
| Uniprot ID | IAPP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Amylin at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | Amylin Polyclonal Antibody detects endogenous levels of Amylin protein. |
Additional Info
| Function | Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs. |
| Protein Name | Islet Amyloid PolypeptideIappAmylinDiabetes-Associated PeptideDapInsulinoma Amyloid Peptide |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Islet Amyloid Polypeptide antibodyAnti-Iapp antibodyAnti-Amylin antibodyAnti-Diabetes-Associated Peptide antibodyAnti-Dap antibodyAnti-Insulinoma Amyloid Peptide antibodyAnti-IAPP antibody |
Information sourced from Uniprot.org