Anti-HUWE1/LASU1 antibody (Internal) (STJ72016)

SKU:
STJ72016-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-HUWE1/LASU1 (Internal) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: HUWE1
Gene ID: 10075
Uniprot ID: HUWE1_HUMAN
Immunogen Region: Internal
Accession Number: NP_113584.3
Immunogen Sequence: DDLKSNTEYHKYQ
Post Translational Modifications Phosphorylated on tyrosine.phosphorylation is probably required for its ability to inhibit TP53 transactivation.
Function E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC. Ubiquitination of MFN2 also takes place following induction of mitophagy.AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling.
Protein Name E3 Ubiquitin-Protein Ligase Huwe1
Arf-Binding Protein 1
Arf-Bp1
Hect - Uba And Wwe Domain-Containing Protein 1
Hect-Type E3 Ubiquitin Transferase Huwe1
Homologous To E6ap Carboxyl Terminus Homologous Protein 9
Hecth9
Large Structure Of Ureb1
Lasu1
Mcl-1 Ubiquitin Ligase E3
Mule
Upstream Regulatory Element-Binding Protein 1
Ure-B1
Ure-Binding Protein 1
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Mitochondrion
Mainly Expressed In The Cytoplasm Of Most Tissues
Except In The Nucleus Of Spermatogonia
Primary Spermatocytes And Neuronal Cells
Recruited To Mitochondria Following Interaction With Ambra1
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Huwe1 antibody
Anti-Arf-Binding Protein 1 antibody
Anti-Arf-Bp1 antibody
Anti-Hect - Uba And Wwe Domain-Containing Protein 1 antibody
Anti-Hect-Type E3 Ubiquitin Transferase Huwe1 antibody
Anti-Homologous To E6ap Carboxyl Terminus Homologous Protein 9 antibody
Anti-Hecth9 antibody
Anti-Large Structure Of Ureb1 antibody
Anti-Lasu1 antibody
Anti-Mcl-1 Ubiquitin Ligase E3 antibody
Anti-Mule antibody
Anti-Upstream Regulatory Element-Binding Protein 1 antibody
Anti-Ure-B1 antibody
Anti-Ure-Binding Protein 1 antibody
Anti-HUWE1 antibody
Anti-KIAA0312 antibody
Anti-KIAA1578 antibody
Anti-UREB1 antibody
Anti-HSPC272 antibody

Information sourced from Uniprot.org

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