Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)

Anti-Human FOLR1 nanobody [SAA2048] (STJN000563)

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STJN000563
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Short Description :Alpaca monoclonal nanobody anti-Folate Receptor Alpha is suitable for use in ELISA and Flow Cytometry research applications.
Applications:ELISA/FC
Host:Alpaca
Reactivity:Human/Cynomolgus
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA2048
Isotype:VHH-8His-Cys-tag
Conjugation:Unconjugated
Concentration:1.41 mg/mL
Purification:Purified by Nickel column.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol:FOLR1
Gene ID:2348
Uniprot ID:FOLR1_HUMAN
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name Folate Receptor Alpha
Fr-Alpha
Adult Folate-Binding Protein
Fbp
Folate Receptor 1
Folate Receptor - Adult
Kb Cells Fbp
Ovarian Tumor-Associated Antigen Mov18
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Nanobody Names Anti-Folate Receptor Alpha nanobody
Anti-Fr-Alpha nanobody
Anti-Adult Folate-Binding Protein nanobody
Anti-Fbp nanobody
Anti-Folate Receptor 1 nanobody
Anti-Folate Receptor - Adult nanobody
Anti-Kb Cells Fbp nanobody
Anti-Ovarian Tumor-Associated Antigen Mov18 nanobody
Anti-FOLR1 nanobody
Anti-FOLR nanobody

Information sourced from Uniprot.org

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